This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

This Review defines seven hallmarks of skeletal muscle homeostasis, providing a unifying framework for understanding, measuring and preserving muscle health.

This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases.

In a meta-analysis including 1.5 million incidences of cancer, positive associations between body mass index and 19 cancers were identified, underlining the impact of obesity on cancer risk.

A futile Na⁺ K⁺ transport cycle, which is preferentially active in beige adipocytes, is shown to promote energy expenditure independent of uncoupling protein 1.

Nicotinamide N-methyltransferase promotes and sustains hyperandrogenism in polyendocrine metabolic ovarian syndrome through metabolic and epigenetic reprogramming.

This study reports a cellular map of the mouse and human mediobasal hypothalamus, revealing an immune cell-like state of tanycytes, which is influenced by sex and the ovarian cycle.

Using genetically encoded tools that shift the redox equilibrium, the authors identify a link between oxidative and reductive stress, suggesting that simultaneously targeting NAD(P)H homeostasis could be a therapeutic strategy for age-related redox-driven metabolic vulnerabilities.

This study provides a comprehensive, systems-level characterization of acute exercise-induced proteomic responses across several body fluids in humans.

In a randomized placebo-controlled crossover trial, pharmacological inhibition of ketohexokinase improved hepatic and systemic metabolic health in individuals with MASLD, highlighting fructose metabolism as a promising therapeutic target with benefits extending beyond the liver.

Great science comes in all shapes and sizes. Choosing the most suitable article type is key to managing the expectations of readers, editors and reviewers alike.

Secreted molecules are central regulators of interorgan communication and metabolic physiology. As the field has expanded rapidly, criteria for assigning molecules as bona fide secreted signals and linking them to functions have remained inconsistent. Here, we describe core concepts in secreted factors and how to study them.