Table 2 LD50 values of various B. anthracis strains and their respective ΔhtrA mutants (SC administration).

From: Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA- (High Temperature Requirement A) Sterne Strain

 

B. anthracis strain

Vollum (pXO 1 + /pXO 2 + )

Sterne (pXO 1 + /pXO 2 − )

WT

ΔhtrA

WT

ΔhtrA

Animal Model Mice (ICR)

10

3 × 105

1.6 × 102

6 × 105

Guinea Pigs

50–100

3 × 108

8 × 105

>1010

Rabbits

50–100

>5 × 108

5 × 108

>5 × 109

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