- For the Western home computer versions, see Alien Syndrome (home computers).
Alien Syndrome (エイリアンシンドローム) is a 1987 arcade game released by Sega. It runs on Sega System 16 hardware. The user plays as either Ricky and Mary rescuing hostages within a set time limit while blasting aliens. There are numerous weapons and two players can play simultaneously.
Compared to other Arcade ports to the Master System, Alien Syndrome shows some very poor production values. It's incompatible with the Mega Drive controller (since the Master System D-pad is terrible for the diagonals), lacks a cooperative 2P mode (it only have the competitive one) and lacks a scrolling camera.
Gameplay
Rounds
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Round 1
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The round's boss is named Hugger[1] (ハガー)[17], named after artist Haga. A similar boss with the same name appears in one of the developer's next games Altered Beast. In the Western Master System release they are renamed Squime[18].
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Round 2
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The round's boss is named Asophy[1] (アソフィー)[17], named after designer Hiroshi Aso (also known as Asohi). In the Western Master System release they are renamed Aargh[18].
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Round 3
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The round's boss is named Tacapy[1] (タカピー)[17], likely named after a developer.
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Round 4
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The round's boss is named Minnow[1] (ミノ)[19], named after artist Minoru Matsuura (also known as Minow). In the Master System release they are replaced with アッシィー[17], renamed Masher in the West[18].
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Round 5
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The round's boss is named Yocotie[20] (ヨコティエ)[19], named after programmer Makihito Yokota. In the Master System release they are replaced with ハリファー[17], renamed Haggah in the West[18].
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Round 6
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The round's boss is named Minemor[20] (ミナモーレ)[17], likely named after a developer whose name begins with MIN. In the Western Master System release they are renamed Minesar[18].
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Round 7
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The round's boss is named Mizzy (ミズィー)[19], likely named after a developer. In the Famicom release they are replaced with King Core (キングコアー)[21] and in the Master System release are replaced by an unnamed boss[17][18].
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History
Legacy
The game was ported to the Famicom (by Sunsoft and Sanritsu), Sega Game Gear (published by Sims) and Sega Master System. In 1988, Tengen brought Sunsoft's port over to the United States with an unlicensed release, removing both Sunsoft's and Sanritsu's names. Due to technical restrictions, some versions are single-player only. It was also re-released as part of the Sega Ages 2500 series and as part of Sega Classics Collection (however it was removed from the European release to keep the PEGI rating down). The Sega Classics Collection port is notable for its two joysticks control scheme, similar to Robotron 2084 and Smash TV.
A scrapped sequel was planned for the Sega System 24 by the first game's designer Hiroshi Aso, set to include more strategic elements and branching stages[22]. Instead, a sequel with the same name was released for the Wii and PSP in 2007.
Versions
Localised names
Also known as
| Language
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Localised Name
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English Translation
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| English
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Alien Syndrome
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Alien Syndrome
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| English (US)
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Alien Syndrome
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Alien Syndrome
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| Japanese
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エイリアン シンドローム
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Alien Syndrome
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| Portuguese (Brazil)
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Alien Syndrome
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| Korean
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에이리언 신드롬
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Alien Syndrome
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Comparisons
- Main article: Alien Syndrome/Comparisons.
Production credits
- Main article: Alien Syndrome/Production credits.
Hints
Digital manuals
Magazine articles
- Main article: Alien Syndrome/Magazine articles.
Promotional material

PDF
System 16 US flyer

PDF
System 16 US flyer (conversion kit)

PDF
System 16 JP flyer

PDF

PDF


PDF
Master System print advert in
ACE (UK) #6: "March 1988" (1988-02-04)
also published in:
PDF
Photo gallery
System 16 motherboard PCB (top)
System 16 motherboard PCB (bottom)
System 16 ROM board PCB (top)
System 16 ROM board PCB (bottom)
Artwork
Physical scans
System 16 version
| System 16, US
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 Manual
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| System 16, JP
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  Instuction card(s)
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Mega-Tech version
| Mega-Tech, |
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  Cart |
Master System version
| {{{{{icon}}}|L}}
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Division by zero.
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Based on 0 review
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| Master System, JP |
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 Cart  Manual |
| Master System, US |
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 Cover |
 Cart  Manual |
| Master System, EU |
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 Cover |
 Cart |
| Master System, EU ("No Limits") |
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 Cover |
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| Master System, SE (Brio) |
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 Manual |
| Master System, AU |
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 Cover |
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| Master System, BR |
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 Cover |
 Manual |
| Master System, KR |
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 Cart |
Game Gear version
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Division by zero.
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Based on 0 review
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| Game Gear, JP |
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 Box |
 Cart  Manual |
| Game Gear, EU |
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 Cart  Manual |
NES version
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Division by zero.
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Based on 0 review
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| NES, US |
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 Cart  Manual |
| NES, JP |
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 Cart  Manual |
X68000 version
| X68000, JP |
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 Cover |
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Technical information
- Main article: Alien Syndrome/Technical information.
ROM dump status
| System |
Hash |
Size |
Build Date |
Source |
Comments |
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| ✔
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| CRC32
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5b837e8d
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| MD5
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e91b3e0ad255eeae1823d2372a4b21da
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| SHA-1
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f116eb809c5a46017807335e11dc1d89ffa63e8c
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256kB
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Cartridge (JP)
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| CRC32
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cbf4366f
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| MD5
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66f4d31a0a0d66b2a85a88212ce159fe
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| SHA-1
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7955dbe5ec63f71ba591a9237d113aaa90849263
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256kB
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Cartridge (US)
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(Unl)
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References
- ↑ 1.0 1.1 1.2 1.3 1.4 File:Alien Syndrome Arcade JP Flyer.pdf, page 2
- ↑ File:AlienSyndrome Arcade US Flyer.pdf
- ↑ 4.0 4.1 http://sega.jp/fb/segahard/gg/soft_licensee.html (Wayback Machine: 2013-01-01 20:24)
- ↑ 5.0 5.1 https://sega.jp/history/hard/segamark3/software.html (Wayback Machine: 2019-06-21 03:44)
- ↑ Mega Drive Fan, "May 1992" (JP; 1992-04-xx), page 103
- ↑ Arcade TV Game List: Kokunai Kaigai-hen (1971-2005), Masumi Akagi, page 133
- ↑ Computer Entertainer, "April 1988" (US; 1988-04-16), page 07
- ↑ File:BristolEveningPost UK 1988-09-09 Page 89.jpg
- ↑ 10.0 10.1 ACE, "May 1988" (UK; 1988-xx-xx), page 63
- ↑ 11.0 11.1 The Games Machine, "March 1988" (UK; 1988-02-18), page 55
- ↑ The Mastertronic Catalogue (UK; 1988), page 2
- ↑ Beep! MegaDrive, "March 1992" (JP; 1992-02-08), page 22
- ↑ 14.0 14.1 Computer Trade Weekly, "414" (UK; 1992-11-23), page 18
- ↑ Sega Force, "January 1993" (UK; 1992-12-10), page 71
- ↑ Computer Entertainer, "January 1990" (US; 1990-01-20), page 22
- ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 File:AlienSyndromeSMSJPManual.pdf, page 10
- ↑ 18.0 18.1 18.2 18.3 18.4 18.5 File:Aliensyndrome_sms_us_manual.pdf, page 9
- ↑ 19.0 19.1 19.2 https://www.mui-2.com/alien_syndrome/ (Wayback Machine: 2023-10-16 08:54)
- ↑ 20.0 20.1 https://www.arcadequartermaster.com/aliensyn_bosses.html (Wayback Machine: 2025-12-06 06:29)
- ↑ https://www.mui-2.com/alien_syndrome/fc.html (Wayback Machine: 2023-10-16 09:01)
- ↑ File:SegaAges2500_V14_PS2_JP_Leaflet.pdf, page 2
- ↑ Computer & Video Games, "March 1988" (UK; 1988-02-15), page 10
- ↑ Complete Guide to Consoles, "1" (UK; 1989-10-16), page 47
- ↑ Complete Guide to Consoles, "Volume IV" (UK; 1990-11-xx), page 90
- ↑ The Complete Guide to Sega, "1" (UK; 1991-05-xx), page 52
- ↑ Computer Action, "Juli/August 89" (DK; 1989-0x-xx), page 34
- ↑ Console XS, "June/July 1992" (UK; 1992-04-23), page 137
- ↑ Computer & Video Games, "April 1988" (UK; 1988-03-15), page 123
- ↑ Games Preview, "7 1989" (DK; 1989-xx-xx), page 42
- ↑ Mean Machines Sega, "October 1992" (UK; 1992-09-xx), page 132
- ↑ Power Play, "Ausgabe 3" (DE; 1988-02-22), page 97
- ↑ S: The Sega Magazine, "April 1990" (UK; 1990-03-01), page 8
- ↑ Sega Power, "October 1991" (UK; 1991-09-05), page 55
- ↑ Sega Pro, "November 1991" (UK; 1991-xx-xx), page 19
- ↑ Sega Pro, "April 1993" (UK; 1993-03-11), page 70
- ↑ Software Gids, "Mei/Juni 1990" (NL; 1990-05-xx), page 36
- ↑ Aktueller Software Markt, "Juli 1992" (DE; 1992-06-12), page 129
- ↑ Beep! MegaDrive, "April 1992" (JP; 1992-03-07), page 38
- ↑ Consoles +, "Mai 1992" (FR; 1992-0x-xx), page 128
- ↑ Computer & Video Games, "June 1992 (Go! Issue 8)" (UK; 1992-05-15), page 6
- ↑ DIGITISER, "1993-02-10"
- ↑ Mean Machines: The Essential Sega Guide, "1" (UK; 1993-11-18), page 164
- ↑ Weekly Famitsu, "1992-03-27" (JP; 1992-03-13), page 38
- ↑ Hippon Super, "April 1992" (JP; 1992-03-04), page 87
- ↑ Joypad, "Juin 1992" (FR; 1992-05-1x), page 84
- ↑ Joystick, "Mai 1992" (FR; 1992-0x-xx), page 201
- ↑ Mega Force, "Décembre 1992" (FR; 1992-1x-xx), page 94
- ↑ Player One, "Janvier/Février 1993" (FR; 1993-01-10), page 134
- ↑ Play Time, "(8/9)/92" (DE; 1992-07-08), page 96
- ↑ Play Time, "3/93" (DE; 1993-02-10), page 109
- ↑ Power Play, "6/92" (DE; 1992-05-13), page 158
- ↑ Sega Power, "March 1993" (UK; 1993-02-04), page 52
- ↑ Sega Pro, "May 1992" (UK; 1992-04-16), page 32
- ↑ Sega Pro, "April 1993" (UK; 1993-03-11), page 74
- ↑ Sega Zone, "January 1993" (UK; 1992-12-xx), page 29
- ↑ Sega Force, "January 1993" (UK; 1992-12-10), page 70
- ↑ Supersonic, "Janvier 1993" (FR; 199x-xx-xx), page 29
- ↑ Video Games, "6/92" (DE; 1992-05-29), page 122
- ↑ Cool Gamer, "10" (RU; 2003-01-30), page 20