Uncover the latest and most impactful research in Stem Cell Biology. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Background Autologous bone transplantation is an important method for cranial bone repair and reconstruction. This study systematically investigated the effects of different cryopreservation strategies and disinfection methods on autologous bone...
Male reproductive injuries—including erectile dysfunction (ED), chemotherapy/radiotherapy-induced testicular damage, epididymal dysfunction, and oligoasthenoteratozoospermia—represent a growing global health burden. Current therapies offer limited...
Hematopoietic cell transplantation is a curative treatment for many hematologic malignancies and selected non-malignant hematologic, immunologic, and genetic disorders. Hematopoietic reconstitution is initially driven mainly by progenitor cells with...
Adipose-derived stem cells (ADSCs) possess key advantages including wide availability and robust in vitro expansion. Their multipotency makes them promising seed cells for tissue engineering. Although the adipogenic and osteogenic differentiation of...
Stem cells, known for their exceptional self-renewal and multilineage differentiation capabilities, play critical roles in tumor initiation, progression, and therapeutic strategies. Extracellular vesicles (EVs) from non-malignant stem cells inherit...
Umbilical cord blood (UCB) has become an important resource for regenerative medicine owing to its unique cellular composition, immune immaturity, and abundance of bioactive factors. Although UCB was initially applied in hematopoietic stem cell...
This Open Access book provides a focused translational roadmap on mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs), covering their biology, molecular cargo, isolation and characterization, mechanisms of action,...
The quiescent state of adult stem cells is fundamental to their protection against exogenous damage, the maintenance of stem cell pool stability, and the preservation of long-term regenerative potential in tissues. Elucidating the underlying...
Hematopoietic stem cells (HSCs) are the definitive source of all blood cells and replenish them for life. The endothelial protein C receptor (EPCR) which signals via its coreceptor protease-activated receptor 1 (PAR1) is expressed on a subpopulation...
Abstract Bone marrow progenitor cells ensure the maintenance of hematopoiesis and bone tissue homeostasis. During spaceflight, they are exposed to microgravity and volatile organic compounds (VOCs), which are present in the atmosphere aboard a crewed...
Background Lower-limb ischemia caused by peripheral arterial disease (PAD) results in sustained perfusion impairment and tissue injury, and effective regenerative therapies remain limited. Bone marrow mesenchymal stem cell-derived exosomes...
Hemorrhagic stroke encompasses anatomically and biologically distinct disorders, principally adult intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage (SAH); neonatal intraventricular hemorrhage (IVH) represents a separate...
This is a concise handbook covering recent developments in research regarding temporomandibular joint disease and disorders, focusing on understanding how these current insights can resolve outstanding diagnostic dilemmas and improve clinical...
Alzheimer’s disease (AD) affects more than 55 million people worldwide, and current pharmacological treatments provide only modest symptomatic benefits with limited effects on disease progression. Stem cell-based therapies, including mesenchymal...
Alzheimer’s disease (AD) is a significant healthcare concern due to the complex interactions between amyloid-β accumulation, tau pathology, neuroinflammation, synaptic dysfunction, and progressive neuronal death. Stem-cell-based therapies have...
Purpose of Review Stem cell research in space has progressed from feasibility demonstrations toward an increasingly mature translational platform supported by specialized flight hardware, standardized crew procedures, and growing access to Low Earth...
Therapeutic resistance and cellular plasticity remain major challenges in high-grade serous ovarian cancer (HGSOC), yet the RNA-mediated mechanisms sustaining stem-like states remain incompletely understood. Here, we investigated microRNA-driven...
The repair of critical-sized bone defects remains a significant clinical challenge. As a cell-free alternative, extracellular vesicles (EVs) derived from adipose-derived stem cells (ADSCs-EVs) hold promise, yet their precise mechanism in promoting...
This study explores how parents seeking information about stem cell therapies (SCT) for autism spectrum disorder (ASD) understand and navigate a complex landscape of scientific uncertainty, commercial claims, and clinical advice. We conducted a...
In humans, long-term hematopoietic stem cells (LT-HSCs) are enriched within the CD34⁺CD38lowfraction in vivo, and CD38 abundance typically rises with lineage commitment, suggesting that CD38 may function as a negative regulator of stem cell...
Journal
The purpose of Stem Cell Reviews and Reportsis to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal...
Journal
Aims and scope: Stem Cell Research & Therapyis the major forum for translational research into stem cell therapies. An international peer-reviewed...
