Regulatory T cells (TReg cells) are a special subset of T cells that prevent other immune cells from attacking the body’s own tissues and other harmless environmental materials, such as food and commensal organisms. Defects in regulatory T cells cause severe inflammatory disease. Uncover the latest and most impactful research in Regulatory T cells. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Type 1 diabetes mellitus (T1DM) is characterized by the destruction of pancreatic β-cells, in which the dysfunction of regulatory T cells (Tregs) contributes to impaired immune tolerance. However, Treg heterogeneity remains incompletely understood,...
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. The interferon regulatory factor (IRF) family comprises transcription factors that regulate immune responses; however, their roles in MS pathogenesis...
Pulmonary fibrosis, a progressive and irreversible manifestation of interstitial lung disease, leads to severe respiratory dysfunction. Although current therapies can slow disease progression, they cannot eliminate pathogenic fibroblasts, thereby...
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and cellular metabolic abnormalities, including enhanced glycolytic activity in CD4+T cells. However, the molecular regulators that...
Immunomodulatory therapies have emerged as promising treatments for cancer, where poly(I:C), a synthetic double-stranded RNA, is currently under clinical investigation for its ability to control myeloid cell function and T cell infiltration. While...
Local activation of regulatory T (Treg) cells represents a promising strategy for wound repair and tissue regeneration. However, current Treg-based therapies rely on adoptive cell transfer, which requires ex vivo expansion and reinfusion, posing...
Background Dietary restriction (DR) can influence cancer progression by remodeling the tumor microenvironment (TME), but its immunomodulatory effects and underlying mechanisms in melanoma remain incompletely understood. This study aimed to...
Cancer remains a formidable challenge in global oncology, with conventional treatments often failing to achieve durable responses in advanced stages. Adoptive cell therapy (ACT), despite its revolutionary success in hematological malignancies, faces...
The interleukin-13 receptor α2 (IL-13Rα2) is overexpressed in a variety of solid tumors with restricted expression in normal tissues, making it a promising tumor target. However, there’s been limited progress in IL-13Rα2 targeting tumor therapy....
Background Plasmodium vivaxis a major cause of global malaria morbidity, posing unique elimination challenges due to dormant liver-stage hypnozoites that cause clinical relapses. The development of an effective vaccine is a prerequisite for...
Incidence of colorectal cancer (CRC) has increased in individuals < 50 years, described as early-onset CRC (EOCRC). Although the precise etiology is unclear, EOCRC is associated with external exposures that may alter the tumor immune...
Introduction and objectives Periodontitis is one of worldwide prevalent inflammatory diseases, driven by dysregulated host immune responses. MicroRNA‑21 (miR‑21) is a critical modulator of inflammatory responses in various chronic inflammatory...
Background Gut microbiota induce intestinal Th17 cells in both physiological and disease states, yet whether there are shared mechanisms remains unclear. We previously identified the Fbxw7-Trim21 axis as critical for Alcaligenes faecalis-driven...
Background Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in tumors and contribute to the formation of an immunosuppressive niche. Ginsenoside Rg3, a triterpenoid glycoside derived from Panax ginseng, has been...
Follicular helper T (TFH) cells are well known for their role in supporting B cell responses. Here, we identify a critical B cell-independent function for TFH cells in sustaining regulatory T (Treg) cells within gut-associated lymphoid tissues...
This study aimed to investigate the immune-epigenetic profile of pediatric immune thrombocytopenic purpura (ITP) and its association with disease chronicity. This case–control study included 93 participants: 33 children with newly diagnosed ITP, 28...
Senescence is a stress-induced program defined by permanent cell-cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP). Defective clearance of senescent cells promotes inflammation, tissue dysfunction, and ageing, yet...
Two major, contradictory forces act simultaneously on immune cells in the tumor microenvironment (TME): one enhances the immune response following the identification of danger, while the other protects the tumor by imposing an immunosuppressive...
Journal
Nature Immunology, ranked first out of more than 100 primary immunology research journals, brings together the most significant immunology research...
Journal
Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence...
Journal
Cellular & Molecular Immunology is a monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China....
