Liver cancer, or hepatic cancer, is a malignant tumour that grows on the surface or inside the liver. The leading cause is a viral infection with hepatitis B or C virus. The most frequent liver cancers are hepatocellular carcinoma and hepatoblastoma (formed by immature liver cells). Uncover the latest and most impactful research in Liver cancer. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Background The prognostic impact of CT-defined sarcopenia in hepatocellular carcinoma (HCC) patients who received the transarterial chemoembolization (TACE) remains unclear. This study aimed to clarify the impact of CT-defined sarcopenia on survival...
Background Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to contribute to HCC progression. DDB1 and CUL4 associated factor 13 (DCAF13) is a substrate...
Backgrounds Dynamic skeletal muscle deterioration during hepatocellular carcinoma (HCC) treatment may capture changes in host vulnerability during treatment. Yet the available evidence is fragmented across treatment settings, imaging metrics, and...
Hepatocellular carcinoma (HCC) is characterized by high proliferation and metastasis potential and is prone to chemotherapy resistance, which seriously restricts the clinical efficacy of cisplatin (DDP)-based treatment. Rosmarinic acid (RA) is a...
Background Given the growing use of cancer screening, colorectal tumors are increasingly diagnosed before metastasizing to distant organs. However, up to 25% of patients with early-stage colorectal cancer later develop metachronousmetastases –...
Background Ascites development in patients with cancer is associated with considerable morbidity and mortality, representing an unmet clinical need. The development of targeted treatment strategies was so far hampered by a lack of pathophysiologic...
Colorectal cancer (CRC), one of the most prevalent and lethal malignancies worldwide, is driven by complex genetic and molecular alterations. In this study, we aimed to identify the functional role of spindle and kinetochore associated complex...
Background Azathioprine (AZA) is widely used for maintenance treatment of autoimmune hepatitis (AIH), but its association with extrahepatic malignancy remains uncertain. We evaluated the association between early AZA prescription and subsequent...
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver malignancy with poor outcome. It is characterized by heterogeneous clinicopathological features as well as molecular landscapes. The updated World Health Organization (WHO)...
Hepatocellular carcinoma (HCC) is a complex malignancy with limited therapeutic options. Although the reduced efficacy of first-line treatment option sorafenib therapy has been largely attributed to autophagy in HCC cells, the specific...
Purpose Midkine (MDK) and thyroid hormone receptor beta (THRB) have each been implicated separately in metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). THRB drives hepatic fatty-acid beta-oxidation (FAO). We...
Combined hepatocellular–cholangiocarcinoma (cHCC-CCA) is a rare liver cancer characterized by cancerous cells of bile duct origin. Treatment options are limited and prognosis is poor. When a mutation of isocitrate dehydrogenase-1 (IDH1) is present,...
Background Hepatocellular carcinoma (HCC) is one of the most lethal malignancies and severely threatens human health. Inflammatory and immunoregulatory signals co‑exist within the HCC tumor microenvironment (TME), impairing tissue repair and...
Purpose Circular RNAs (circRNAs) are aberrantly expressed in various human cancers and regulate tumor cell proliferation, invasion, and metastasis through multiple mechanisms. However, existing studies are mostly single-center with small sample...
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive biliary malignancy for which longitudinal non-invasive monitoring remains challenging in preclinical models. Using time-domain nuclear magnetic resonance (TD-NMR), we characterized...
Purpose Transarterial chemoembolization (TACE) is a primary treatment for intermediate to advanced hepatocellular carcinoma (HCC); however, cancer-related fatigue (CRF) is a prevalent and distressing symptom following TACE that significantly impairs...
