The endoderm is the innermost layer of cells in very early vertebrate and insect embryos. It is one of the three primary germ cell layers and gives rise to epithelial tissue lining some organs, including the digestive, urinary and respiratory tracts. Uncover the latest and most impactful research in Endoderm. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Late-onset Fuchs endothelial corneal dystrophy (FECD) is marked by progressive thickening of Descemet’s membrane (DM), accumulation of guttae, and endothelial dysfunction, primarily affecting the central cornea. However, the centro-peripheral...
The mammary gland relies on reciprocal interactions between epithelial cells and their surrounding extracellular matrix (ECM) to form and maintain milk-producing tissue structures. Yet these processes remain difficult to study in human model...
Background Since the first description in 1827, the zona pellucida (ZP) has been viewed as an extracellular structure surrounding mammalian oocytes, with three canonical roles: encasement of the oocyte in the follicle, sperm binding at fertilization,...
Background The present work aimed at modelling in vitro the interplay between immune complexes (ICs) containing scleroderma-specific antibodies, vasculopathy and skin fibrosis to reproduce the multifaceted etiopathogenesis of systemic sclerosis (SSc)....
Aims/hypothesis Paracrine signalling by hormone-producing endocrine cells potentially influences pancreatic development, but this feedback regulation remains poorly understood. Here, we investigated the roles of gastrin (GAST), cholecystokinin (CCK)...
Congenital heart defects (CHD) are characterized by pathological intracardiac blood flow, exposing the endocardium to disturbed shear stress. This contributes to the development of endocardial fibroelastosis (EFE), a restrictive fibrotic remodeling...
The human lens is a transparent, avascular organ essential for focusing light and achieving visual acuity. While animal models have illuminated lens development, direct models of human lens organogenesis remain limited. We present an in vitro...
Background Epithelial-mesenchymal transition (EMT) in the amnion of the fetal membranes not only disrupts integrity of the membranes, but also facilitates the production of pro-labor factors, thus participating in the onset of labor. However, the...
Introduction Lithopedion, which is a Greek word for “Stone child” is the name given to an ectopic pregnancy that evolves to fetal death, calcification, and carried for years. It is a very rare phenomena that are only about 300 cases of it registered...
Background The basic vertebrate body plan arises in early development from three embryonic germ layers: ectoderm, endoderm and later mesoderm. In the head, interactions between ecto- and endoderm – without intervening mesoderm – have long been...
Definitive endoderm (DE) specification is essential for gastrointestinal and respiratory organogenesis, yet upstream regulators that integrate signaling pathways with metabolic and epigenetic cues remain poorly understood. Here, we identified...
Despite major advances in liver-on-a-chip and organoid technologies, most current in vitro liver models remain limited. Here, it is argued that these limitations are fundamentally conceptual rather than purely technical. Reverse bioengineering is...
Purpose Endoscopic arytenoid abduction lateropexy (EAAL) is a reliable, minimally invasive technique for treating bilateral vocal fold palsy (BVFP). This study aimed to evaluate the safety and functional efficacy of a modified approach for EAAL that...
Three-dimensional organoids of the gut, liver, and lung have become mainstream models of human development, disease, and therapy. These organs share an embryonic endodermal origin, yet the field measures their progress inconsistently because the...
The human endometrium plays a central role in embryo implantation, pregnancy, and reproductive and systemic health, making it of great biological and clinical interest. Animal models of the endometrium often fail to mimic many intrinsic...
Purpose To compare current endometriosis classification systems across clinically relevant domains and to identify which components may be used for a single internationally accepted classification. Methods A PubMed search was performed up to December...
Background Endometriosis is a chronic disease affecting millions of women worldwide, characterized by the presence of ectopic endometrial-like tissue. While the formation of neutrophil extracellular traps (NETs) has been linked to endometriosis...
Endometriosis is a chronic inflammatory and sex steroid hormone-dependent gynaecologic disease, characterised by endometrial cell proliferation outside the uterine cavity, often accompanied by fibrosis, progesterone resistance, and high recurrence...
A major gap in our understanding of animal development is how adult body plans arise in animals with indirect development, where adults emerge from the transformation of a distinct larval form during metamorphosis. We address this question by...
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We are pleased to announce that Development Genes and Evolution became fully open access (OA) on 1 January 2025 and moved into our Discover series as D...
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The journal publishes regular articles and reviews in the areas of molecular, cell, and supracellular biology. In particular, the journal intends to...
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Brain Structure and Functionwelcomes original research leading to significant advances in understanding brain structure-function relationships. The...
