Embryonic stem cells are pluripotent cells isolated from the inner cell mass of a blastocyst, the early mammalian embryo that implants into the uterus. Embryonic stem cells self-renew by dividing and can differentiate into any specialised cell of the body, but not extra-embryonic tissues such as the placenta. Uncover the latest and most impactful research in Embryonic Stem Cells. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Hemorrhagic shock (HS) induces acute lung injury (ALI) in the early phase. Mesenchymal stem cells (MSCs) have shown potential in ameliorating HS-induced ALI; however, the mechanisms involved remain unclear. Our study investigated the therapeutic...
Purpose To characterize structural access to pediatric ovarian and testicular tissue cryopreservation in the USA, including service availability, delivery models, and institutional research practices. Methods We conducted a national cross-sectional...
Takotsubo Syndrome (TTS) is an acute, potentially life-threatening condition often complicated by ventricular dysfunction and arrhythmias. Atrial fibrillation (AF) is common in TTS patients and associated with increased mortality. However, the...
Periodontal ligament stem cells (PDLSCs) are promising for oral and maxillofacial bone regeneration, but the mechanisms regulating their osteogenic differentiation remain unclear. This study aimed to determine the role of DLX2 and its regulation by...
Background Duchenne muscular dystrophy (DMD) has driven the development of adeno-associated virus (AAV)-based shortened dystrophin gene therapies, including approved delandistrogene moxeparvovec and discontinued fordadistrogene movaparvovec. A...
Background Erectile dysfunction (ED) is a common, debilitating complication of diabetes mellitus, driven by endothelial dysfunction, neurovascular injury, and oxidative stress. Although mesenchymal stem cells confer benefit, concerns regarding...
Background Since the first description in 1827, the zona pellucida (ZP) has been viewed as an extracellular structure surrounding mammalian oocytes, with three canonical roles: encasement of the oocyte in the follicle, sperm binding at fertilization,...
BACKGROUND: Freshly thawed umbilical cord-derived mesenchymal stem cells (FT-UC MSCs) often show reduced post-thaw functionality, limiting their use as off-the-shelf cell therapies. This study investigated whether an ion-enriched solution (IES) could...
Cadherin-16 (Cdh16) is transiently expressed during lung development, while its functional role remains unclear. Herein, we identified Cdh16 as a marker for a dynamic population of alveolar epithelial progenitors. Spatiotemporal and lineage tracing...
X-chromosome inactivation (XCI) is essential for extraembryonic tissue growth and embryo development in mice. However, species-specific differences in its timing and regulation have left its role in human development unclear. Here, we show that the...
The lack of large, balanced, and shareable biomedical imaging datasets remains a major barrier to the development, validation, and clinical translation of artificial intelligence systems. Synthetic data generation has emerged as a promising...
The genetic mouse model Lyve1 Cre is widely used to study lymphatic endothelial cells, but its activity in the embryonic heart has not been comprehensively defined. Here we show that the Lyve1lineage contributes to multiple cardiovascular cell...
Background Premature ovarian insufficiency (POI) leads to severe ovarian injury and fertility decline. Conventional hormone replacement therapy cannot reverse tissue damage, and single stem cell or tissue engineering treatments have unsatisfactory...
Male reproductive injuries—including erectile dysfunction (ED), chemotherapy/radiotherapy-induced testicular damage, epididymal dysfunction, and oligoasthenoteratozoospermia—represent a growing global health burden. Current therapies offer limited...
Induced pluripotent stem cells (iPSCs) have unlimited proliferative capacity and multi-lineage differentiation potential. Autologous iPSC-derived cells reduce the risk of immune rejection, making them promising resources for regenerative medicine....
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutics because of their immunomodulatory and regenerative potential. Yet their clinical translation remains constrained by a persistent gap...
Oocyte quality governs early embryonic development and female fertility. Here, we demonstrate that the maternal effect gene Tcl1 supports oocyte cytoplasmic competence through metabolic regulation. Although Tcl1-deficient females maintain a normal...
Background Peri-implant capsule formation is a physiological response to implanted biomaterials; however, excessive fibrotic reactions may contribute to capsular contracture and implant-related complications. Human amniotic fluid-derived cell culture...
Epithelial-to-mesenchymal transition (EMT) is a key driver of colorectal cancer (CRC) progression and metastasis. Identifying pivotal EMT-related genes and novel therapeutic approaches may enhance patient outcomes. In this study, we analyzed...
Journal
Aims and scope: Stem Cell Research & Therapyis the major forum for translational research into stem cell therapies. An international peer-reviewed...
Journal
The purpose of Stem Cell Reviews and Reportsis to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal...
