Cell adhesion is the process by which cells form contacts with each other or with their substratum through specialized protein complexes. Intercellular adhesion can be mediated by adherens junctions, tight junctions and desmosomes, whereas cells can interact with extracellular matrix molecules through focal adhesions. Uncover the latest and most impactful research in Cell Adhesion. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Surface wettability and surface energy are important factors influencing the interaction between cells and surfaces. These properties determine the behavior of cells, including their adhesion, proliferation and differentiation on various materials,...
Cellular adhesion is a central determinant of functional three-dimensional tissue structures. The challenges lie in restoring stable cell-to-cell and cell-to-matrix adhesion from dissociated cells without compromising cell integrity and impairing...
Focal adhesions (FAs) are dynamic macromolecular assemblies that anchor the actin cytoskeleton to the extracellular matrix via integrin receptors, thereby regulating cell morphology and migration. Here, we show that the vasodilator-stimulated...
What happens when you poke a living cell, applying a localized external force to its surface? The answer depends, in part, on how long you keep poking. The plasma membrane and the actomyosin cortex beneath it form a mechanically active interface...
Adhesion is a fundamental biophysical property describing how biological systems establish, maintain, and remodel interactions with their surrounding environment. Force spectroscopy, based on Atomic Force Microscopy (AFM), has emerged as a powerful...
Background Placento-cerebral adhesion is an exceptionally rare congenital cranial anomaly with heterogeneous anatomy and inconsistent terminology. We report a neonate with vascularized placento-cerebral adhesion, review the published morphology, and...
Abstract The dynamic adhesion of lipid vesicles in shear flow is governed by the interplay of membrane-bending rigidity, membrane–substrate adhesion energy, and hydrodynamic stresses. While the equilibrium contact curvature is determined by the...
Focal adhesion (FA) dynamics and cell migration depend sensitively on the mechanical properties of the extracellular matrix, yet substrate stiffness alone cannot account for the distinct behaviours observed on natural versus artificial materials. In...
Red blood cells play a dominant mechanical role in blood flow and strongly influence the transport and arrest of circulating tumor cells during metastasis. Circulating tumor cells (CTCs) are subject to physical interactions with blood components and...
Beyond serving as cohesive barriers, epithelia clear apoptotic cells to regulate development, homeostasis and inflammation. How epithelial cells remodel their shape during phagocytosis while preserving tissue integrity, and the role of adhesion...
Species-specific adhesion of gametes is a prerequisite to cell fusion during fertilization, yet the underlying molecular mechanisms are not fully understood for any organism. In Chlamydomonas, the adhesion protein MAR1 chaperones the conserved...
Tissue fluidity regulates biological processes such as embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm postulates that fluidity is...
The crossing of the endothelial cell layer and the glycocalyx that shields it can be considered the final barrier for substances trying to pass from the blood into the surrounding tissue. Due to their terminal position on glycan structures, sialic...
Malignancies of the nervous system remain a critical challenge in oncology, contributing substantially to cancer-related mortality in children and adults. Their aggressive behavior is influenced by adhesion heterogeneity of the tumor cells, as...
Integrins mediate cell-substrate adhesion by interacting with extracellular matrix ligands, enabling attachment, spreading, and stabilization. Cells typically adhere more strongly to hydrophobic surfaces and detach more easily from hydrophilic ones,...
In plant organisms, cells have two ways of being connected to each other. They are either adhering to the same neighbouring cells since mitosis or they enter in contact de novo with a new cell and adhered themselves. These different intercellular...
Single-cell operations are crucial technologies across fundamental biology, diagnostics, and therapeutics. The precise characterization and measurement of the physical and biological properties of cells provide critical support for disease...
Clinical & Experimental Metastasis is an international, multidisciplinary journal devoted to the rapid publication of major fundamental advances in...
The field of cellular and molecular bioengineering seeks to understand, so that we may ultimately control, the mechanical, chemical, and electrical...
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Nature Cell Biology publishes peer-reviewed original research of the highest quality in all areas of cell biology with an emphasis on studies that...
