Astrocytes are the largest and most prevalent type of glial cell in the central nervous system. Astrocytes contribute to formation of the blood–brain barrier, participate in the maintenance of extracellular ionic and chemical homeostasis, are involved in the response to injury, and affect neuronal development and plasticity. Uncover the latest and most impactful research in Astrocyte. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Neuropathic pain (NP) remains refractory to conventional therapy partly because its pathogenesis is incompletely understood. G protein-coupled receptor 177 (GPR177), a multi-pass transmembrane protein, regulates Wnt trafficking and secretion. Here,...
Cavernous nerve injury (CNI) is a leading cause of postoperative erectile dysfunction (ED), and effective etiological therapies are lacking. In this study, we constructed mitochondria-transferred macrophages (MTM) with an enhanced M2 reparative...
Immunomodulatory therapies have emerged as promising treatments for cancer, where poly(I:C), a synthetic double-stranded RNA, is currently under clinical investigation for its ability to control myeloid cell function and T cell infiltration. While...
The A152T point mutation is a rare genetic variant in the tau gene (MAPT) that is linked to risk of Alzheimer’s disease (AD) and frontotemporal dementia spectrum disorders, including progressive supranuclear palsy (PSP) and corticobasal degeneration...
Objective Microglial polarization toward the M1 phenotype is a key contributor to the initiation and progression of neuroinflammatory diseases, primarily through the release of pro-inflammatory cytokines that exacerbate central nervous...
Astrocytes are specialized glial cells that help neurons to maintain the calcium signaling process in the nervous system. The endoplasmic reticulum (ER) and mitochondria are two primary intracellular compartments that regulate calcium ions (...
Brain inflammation is a key feature of frontotemporal dementia (FTD). Positron emission tomography (PET) of the 18 kDa translocator protein (TSPO) is widely used as an in vivo proxy for neuroinflammation, but whether the elevated signal reflects...
Mitochondria are dynamic organelles essential for neuronal survival and synaptic function, and their dysfunction is a key consequence of excitotoxicity following traumatic brain injury (TBI). While intercellular mitochondrial transfer and exogenous...
Polystyrene microplastics (PS–MPs) are emerging environmental pollutants with growing evidence of neurotoxic effects. This study examined how particle size and surface charge influence PS–MPs-induced neurotoxicity in male mice. Chronic exposure to...
Background Vascular dementia is the second leading cause of cognitive impairment in the elderly, and chronic cerebral hypoperfusion (CCH) is a major contributing factor. Increasing evidence suggests that T cells play important roles in modulating...
Alzheimer’s Disease (AD) is marked by the accumulation of amyloid-beta (Aβ) plaques, neurofibrillary tangles, and neuroinflammation. Cannabidiol (CBD), the major non-psychoactive compound of Cannabis, has demonstrated significant pharmacological...
Astrocytes play central role in regulation of neural homeostasis and are increasingly implicated in the pathogenesis of neurodegenerative disease. Emerging evidence links the transcription factor GLIS3-/-to several neurological disorders and to...
Hydrogen sulfide (H2S), an endogenous gasotransmitter, exerts potent anti-neuroinflammatory effects. Both endogenous and exogenous H2S attenuate cerebral ischemia/reperfusion (I/R) injury by suppressing neuroinflammatory responses. Microglia play a...
Astrocytes perform a diverse range of tasks that facilitate brain physiology, raising the possibility that these diverse astrocytic roles are enabled by functionally distinct subtypes 1,2 . Recent studies identified molecular diversity among astrocytes
Retinal ganglion cell (RGC) injury is a major feature of optic neuropathies and retinal degenerative diseases and is frequently accompanied by mitochondrial dysfunction, oxidative stress, abnormal axonal transport, and impaired mitochondrial quality...
Cuprizone-induced demyelination provides a valuable experimental model for investigating glial responses and endogenous myelin repair in the central nervous system. This study examined the regional behavior of GFAP- and CD44-positive glial...
Distinguishing resident microglia from infiltrating myeloid cells in stroke scRNA-seq data remains challenging due to shared myeloid markers; SALL1 shows greater specificity for microglia compared with commonly used markers (e.g. TMEM119, CX3CR1,...
Ischemic white-matter injury involves microglia–oligodendrocyte crosstalk, but the contributions of microglial metabolism and extracellular vesicles remain unclear. Primary rat microglia were exposed to 1% O₂, and conditioned-medium and Transwell...
Sex-specific differences in metabolic and immune function are shaped by endocrine–immune interactions, yet the complexity of this relationship remains poorly understood. Here, we identify an immune cell-like state of tanycytes, an ependymoglial cell...
Microglia represent the immune component of the central nervous system (CNS) that displays dynamic responses to injury and disease. Across the developing and mature CNS, microglia emerge as immunocompetent cells that continuously survey their...
Journal
Journal of Neuroinflammationis an open access, peer-reviewed journal that focuses on interactions of the immune system (and especially the innate...
Journal
Announcement We are pleased to announce that Neurochemical Research will become a fully open access (OA) on 1 January 2027. As a result, all...
Journal
Aims and Scope Acta Neuropathologica aims to publish the best papers on pathology of neurological disease, as well as experimental studies on...
