BlockingIOError on App Engine after some time #50

After adding google-cloud-profiler==1.1.1 to my Python 3.7 App Engine project, I'm getting lots of

BlockingIOError: [Errno 11] Resource temporarily unavailable
Exception ignored when trying to write to the signal wakeup fd:

in my service stderr logs

I'm having the same issue either with App Engine Standard python3.7 or with App Engine Flex over a custom runtime (Docker image)

Is this a known issue, is there something I can do to mitigate this issue ?