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Attention-deficit disorder (attention-deficit/ hyperactivity disorder without hyperactivity): A neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity)
Published online by Cambridge University Press: 01 November 2005
Abstract
Most studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the combined type and emphasized a core problem in response inhibition. It is proposed here that the core problem in the truly inattentive type of ADHD (not simply the subthreshold combined type) is in working memory. It is further proposed that laboratory measures, such as complex-span and dual-task dichotic listening tasks, can detect this. Children with the truly inattentive type of ADHD, rather than being distractible, may instead be easily bored, their problem being more in motivation (underarousal) than in inhibitory control. Much converging evidence points to a primary disturbance in the striatum (a frontal–striatal loop) in the combined type of ADHD. It is proposed here that the primary disturbance in truly inattentive-type ADHD (ADD) is in the cortex (a frontal–parietal loop). Finally, it is posited that these are not two different types of ADHD, but two different disorders with different cognitive and behavioral profiles, different patterns of comorbidities, different responses to medication, and different underlying neurobiologies.
Preparation of this manuscript was supported by grants from NIDA (R01 DA19685-16A2) and the McDonnell Foundation (JSMF Grant 21002016). The author gratefully thanks Russ Barkley, Dante Cicchetti, Michael Posner, and Margaret Weiss for comments on an earlier draft of the manuscript. Of course, only the author bears responsibility for any errors in this paper.
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References
REFERENCES
Aaron, P.,
Joshi, R. M., &
Phipps, J.
(2004).
A cognitive tool to diagnose predominantly inattentive ADHD
behaviour.
Journal of Attention Disorders
7,
125–135.Google Scholar
American Psychiatric Association.
(1994).
Diagnostic and statistical manual of mental disorders
(4th edition).
Washington, DC:
Author.
Auerbach, J. G.,
Benjamin, J.,
Faroy, M.,
Geller, V., &
Ebstein, R.
(2001).
DRD4 related to infant attention and information processing: A
developmental link to ADHD?
Psychiatric Genetics
11,
31–35.Google Scholar
Awh, E.,
Anllo–Vento, L., &
Hillyard, S. A.
(2000).
The role of spatial selective attention in working memory for
locations: Evidence from event-related potentials.
Journal of Cognitive Neuroscience
12,
840–847.Google Scholar
Awh, E., &
Jonides, J.
(2001).
Overlapping mechanisms of attention and spatial working
memory.
Trends in Cognitive Science
5,
119–126.Google Scholar
Aylward, E. H.,
Reiss, A. L.,
Reader, M. J.,
Singer, H. S.,
Brown, J. E., &
Denckla, M. B.
(1996).
Basal ganglia volumes in children with attention-deficit
hyperactivity disorder.
Journal of Child Neurology
11,
112–115.Google Scholar
Baddeley, A. D.
(1986).
Working memory.
Oxford:
Clarendon Press.
Baddeley, A. D., &
Hitch, G. J.
(1994).
Developments in the concept of working memory.
Neuropsychology
8,
485–493.Google Scholar
Barbizet, J.
(1970).
Prolonged organic amnesias. In
J. Barbizet (Ed.),
Human memory and its pathology (pp.
25–93).
San Francisco, CA:
W. H. Freeman.
Barkley, R. A.
(1997).
Behavioral inhibition, sustained attention, and executive functions:
Constructing a unifying theory of ADHD.
Psychological Bulletin
121,
65–94.Google Scholar
Barkley, R. A.
(2000).
A new look at ADHD: Inhibition, time, and self-control
[Video].
Barkley, R. A.
(2001).
The inattentive type of ADHD as a distinct disorder: What remains to
be done.
Clinical Psychology: Science and Practice
8,
489–493.Google Scholar
Barkley, R. A.,
DuPaul, G. J., &
McMurray, M. B.
(1990).
A comprehensive evaluation of attention deficit disorder with and
without hyperactivity.
Journal of Consulting and Clinical Psychology
58,
775–789.Google Scholar
Barkley, R. A.,
DuPaul, G. J., &
McMurray, M. B.
(1991).
Attention deficit disorder with and without hyperactivity: Clinical
response to three dose levels of methylphenidate.
Pediatrics
87,
519–531.Google Scholar
Barkley, R. A.,
Grodzinsky, G., &
DuPaul, G.
(1992).
Frontal lobe functions in attention deficit disorder with and
without hyperactivity: A review and research report.
Journal of Abnormal Child Psychology
20,
163–188.Google Scholar
Barnes, L. L.,
Nelson, J. K., &
Reuter–Lorenz, P. A.
(2001).
Object based attention and object working memory: Overlapping
processes revealed by selective interference effect in humans.
Progress in Brain Research
134,
471–481.Google Scholar
Barr, C. L.,
Wigg, K. G.,
Bloom, S.,
Schachar, R.,
Tannock, R.,
Roberts, W.,
Malone, M., &
Kennedy, J. L.
(2000).
Further evidence from haplotype analysis for linkage of the dopamine
D4 receptor gene and ADHD.
American Journal of Medical Genetics
96,
262–267.Google Scholar
Bayliss, D. M., &
Roodenrys, S.
(2000).
Executive processing and attention deficit hyperactivity disorder:
An application of the supervisory attentional system.
Developmental Neuropsychology
17,
161–180.Google Scholar
Benedetto–Nasho, E., &
Tannock, R.
(1999).
Math computation, error patterns and stimulant effects in children
with attention deficit hyperactivity disorder.
Journal of Attention Disorders
3,
121–134.Google Scholar
Cantwell, D. P.
(1983).
Diagnostic validity of the hyperactive child (attention deficit
disorder with hyperactivity) syndrome.
Psychiatric Developments
1,
277–300.Google Scholar
Carlson, C. L.
(1986).
Attention deficit disorder without hyperactivity: A review of
preliminary experimental evidence. In
B. B. Lahey &
A. E. Kazdin (Eds.),
Advances in clinical child psychology
(Vol. 9, pp.
153–175).
New York:
Plenum Press.
Carlson, C. L.,
Lahey, B. B., &
Neeper, R.
(1986).
Direct assessment of the cognitive correlates of attention deficit
disorders with and without hyperactivity.
Journal of Psychopathology Behavioral Assessment
8,
69–86.Google Scholar
Carlson, C. L., &
Mann, M.
(2000).
Attention-deficit/hyperactivity disorder, predominantly
inattentive subtype.
Child & Adolescent Psychiatric Clinics of North America
9,
499–510.Google Scholar
Carlson, C. L., &
Mann, M.
(2002).
Sluggish cognitive tempo predicts a different pattern of impairment
in the attention deficit hyperactivity disorder, predominantly inattentive
type.
Journal of Clinical Child and Adolescent Psychology
31,
123–129.Google Scholar
Case, R.
(1972).
Validation of a neo-Piagetian capacity construct.
Journal of Experimental Child Psychology
14,
287–302.Google Scholar
Case, R.
(1992a).
The role of the frontal lobes in the regulation of cognitive
development.
Brain and Cognition
20,
51–73.Google Scholar
Case, R.
(1992b).
The mind's staircase: Exploring the conceptual underpinnings of
children's thought and knowledge.
Hillsdale, NJ:
Erlbaum.
Case, R.
(1995).
Capacity-based explanations of working memory growth: A brief
history and reevaluation. In
F. E. Weinert &
W. Schneider (Eds.),
Memory performance and competencies: Issues in growth and
development (pp.
23–44).
Mahwah, NJ:
Erlbaum.
Case, R.,
Kurland, D. M., &
Goldberg, J.
(1982).
Operational efficiency and the growth of short-term memory
span.
Journal of Experimental Child Psychology
33,
386–404.Google Scholar
Casey, B. J.,
Castellanos, F. X.,
Giedd, J. N.,
Marsh, W. L.,
Hamburger, S. D.,
Schubert, A. B.,
Vauss, Y. C.,
Vaituzis, A. C.,
Dickstein, D. P.,
Sarfatti, S. E., &
Rapoport, J. L.
(1997).
Implication of right frontostriatal circuitry in response inhibition
and attention-deficit/hyperactivity disorder.
Journal of the American Academy of Child and Adolescent
Psychiatry
36,
374–383.Google Scholar
Casey, B.,
Forman, S.,
Franzen, P.,
Berkowitz, A.,
Braver, T.,
Nystrom, L.,
Thomas, K., &
Noll, D.
(2001).
Sensitivity of prefrontal cortex to changes in target probability: A
functional MRI study.
Human Brain Mapping
13,
26–33.Google Scholar
Castellanos, F. X.
(1997).
Toward a pathophysiology of attention-deficit/hyperactivity
disorder.
Clinical Pediatrics
36,
381–393.Google Scholar
Castellanos, F. X.,
Elia, J.,
Kruesi, J. J. P.,
Gulotta, C. S.,
Mefford, I. N.,
Potter, W. Z.,
Ritchie, G. F., &
Rapoport, J. L.
(1994).
Cerebrospinal fluid monoamine metabolites in boys with
attention-deficit hyperactivity disorder.
Psychiatry Research
52,
305–316.Google Scholar
Castellanos, F. X.,
Giedd, J. N.,
Marsh, W. L.,
Hamburger, S. D.,
Vaituzis, A. C.,
Dickstein, D. P.,
Sarfatti, S. E.,
Vauss, Y. C.,
Snell, J. W.,
Lange, N.,
Kaysen, D.,
Krain, A. L.,
Ritchie, G. F.,
Rajapakse, J. C., &
Rapoport, J. L.
(1996).
Quantitative brain magnetic resonance imaging in
attention-deficit/hyperactivity disorder.
Archives of General Psychiatry
53,
607–616.Google Scholar
Chee, P.,
Logan, G.,
Schachar, R.,
Lindsay, P., &
Wachsmuth, R.
(1989).
Effects of event rate and display time on sustained attention in
hyperactive, normal and control children.
Journal of Abnormal Child Psychology
17,
371–391.Google Scholar
Chochon, F.,
Cohen, L.,
van de Moortele, P. F., &
Dehaene, S.
(1999).
Differential contributions of the left and right inferior parietal
lobules to number processing.
Journal of Cognitive Neuroscience
11,
617–630.Google Scholar
Conte, R.,
Kinsbourne, M.,
Swanson, J.,
Zirk, H., &
Samuels, M.
(1986).
Presentation rate effects on paired associate learning by attention
deficit disordered children.
Child Development
57,
681–687.Google Scholar
Conway, A. R. A.,
Cowan, N., &
Bunting, M. F.
(2001).
The cocktail party phenomenon revisited: The importance of working
memory capacity.
Psychonomic Bulletin and Review
8,
331–335.Google Scholar
Conway, A. R. A., &
Engle, R. W.
(1994).
Working memory and retrieval: A resource-dependent inhibition
model.
Journal of Experimental Psychology: General
123,
354–373.Google Scholar
Conway, A. R. A.,
Tuholski, S. W.,
Shisler, R. J., &
Engle, R.
(1999).
The effect of memory load on negative priming: An individual
differences investigation.
Memory and Cognition
27,
1042–1050.Google Scholar
Corkum, P. V., &
Siegel, L. S.
(1993).
Is the continuous performance task a valuable research tool for use
with children with attention-deficit-hyperactivity disorder?
Journal of Child Psychology and Psychiatry
34,
1217–1239.Google Scholar
Cook, E. H., Jr.,
Stein, M. A.,
Krasowski, M. D.,
Cox, N. J.,
Olkon, D. M.,
Kieffer, J. E., &
Leventhal, B. L.
(1995).
Association of attention-deficit disorder and the dopamine
transporter gene.
American Journal of Human Genetics
56,
993–998.Google Scholar
Cook, E. J.
(2000).
Genetics of psychiatric disorders: Where have we been and where are
we going?
American Journal of Psychiatry
157,
1039–1040.Google Scholar
Crammond, J.
(1992).
Analyzing the basic cognitive developmental processes of children
with specific types of learning disability. In
R. Case (Ed.),
The mind's staircase: Exploring the conceptual underpinnings of
human thought and knowledge (pp.
285–303).
Hillsdale, NJ:
Erlbaum.
Daly, G.,
Hawi, Z.,
Fitzgerald, M., &
Gill, M.
(1999).
Mapping susceptibility loci in attention deficit hyperactivity
disorder: Preferential transmission of parental alleles at DAT1, DBH and
DRD5 to affected children.
Molecular Psychiatry
4,
192–196.Google Scholar
Daneman, M., &
Carpenter, P.
(1980).
Individual differences in working memory and reading.
Journal of Verbal Learning and Verbal Behavior
19,
450–466.Google Scholar
de Fockert, J.,
Rees, G.,
Frith, C., &
Lavie, N.
(2001).
The role of working memory in visual selective attention.
Science
291,
1803–1806.Google Scholar
deHaas, P. A., &
Young, R. D.
(1984).
Attention styles of hyperactive and normal girls.
Journal of Abnormal Child Psychology
12,
531–546.Google Scholar
De La Garza, R., &
Madras, B. K.
(2000).
[(3)H]PNU-101958, a D(4) dopamine receptor probe,
accumulates in prefrontal cortex and hippocampus of non-human primate
brain.
Synapse
37,
232–244.Google Scholar
Dempster, F. N.
(1981).
Memory span: Sources of individual and developmental
differences.
Psychological Bulletin
89,
63–100.Google Scholar
Dempster, F. N.
(1985).
Short-term memory development in childhood and adolescence.
In
C. J. Brainerd &
M. Pressley (Eds.),
Basic processes in memory development: Progress in cognitive
development research.
New York:
Springer–Verlag.
D'Esposito, M.,
Detre, J. A.,
Alsop, D. C.,
Shin, R. K.,
Atlas, S., &
Grossman, M.
(1995).
The neural basis of the central executive system of working
memory.
Nature
378,
279–281.Google Scholar
D'Esposito, M.,
Postle, B. R., &
Rypma, B.
(2000).
Prefrontal cortical contributions to working memory: Evidence from
event-related fMRI studies.
Experimental Brain Research
133,
3–11.Google Scholar
Diamond, A.
(1990).
The development and neural bases of memory functions, as indexed by
the A-not- and delayed response tasks, in human infants and infant
monkeys.
Annals of the New York Academy of Sciences
608,
267–317.Google Scholar
Diamond, A.
(2002).
Normal development of prefrontal cortex from birth to young
adulthood: Cognitive functions, anatomy, and biochemistry. In
D. T. Stuss &
R. T. Knight (Eds.),
Principles of frontal lobe function (pp.
466–503).
London:
Oxford University Press.
Dresel, S. K. J.,
Krause, K. H.,
LaFougere, C.,
Brinkbaumer, K.,
Kung, H. F.,
Hahn, K., &
Tatsch, K.
(2000).
Attention deficit hyperactivity disorder: Binding of
[99mTc]TRODAT-1 to the dopamine transporter before and after
methylphenidate treatment.
European Journal of Nuclear Medicine
27,
1518–1524.Google Scholar
Duncan, J.,
Burgess, P., &
Emslie, H.
(1995).
Fluid intelligence after frontal lobe lesions.
Neuropsychologia
33,
261–268.Google Scholar
Durston, S.,
Fossella, J. A.,
Casey, B. J.,
Hulshoff Pol, H. E.,
Galvan, A.,
Schnack, H. G.,
Steenhuis, M. P.,
Minderaa, R. B.,
Buitelaar, J. K.,
Kahn, R. S., &
van Engeland, H.
(2005).
Differential effects of DRD4 and DAT1 genotype on fronto-striatal
gray matter volumes in a sample of subjects with attention deficit
hyperactivity disorder, their unaffected siblings, and controls.
Molecular Psychiatry
22.Google Scholar
Durston, S.,
Tottenham, N. T.,
Thomas, K. M.,
Davidson, M. C.,
Eigsti, I.-M.,
Yang, Y.,
Ulug, A. M., &
Casey, B. J.
(2003).
Differential patterns of striatal activation in young children with
and without ADHD.
Biological Psychiatry
53,
871–878.Google Scholar
Edelbrock, C.,
Costello, A. J.,
Kessler, M. D.
(1984).
Empirical corroboration of attention deficit disorder.
Journal of the American Academy of Child and Adolescent
Psychiatry
23,
185–190.Google Scholar
Faraone, S. V.,
Biederman, J.,
Wever, W., &
Russell, R. L.
(1998).
Psychiatric, neuropsychological, and psychosocial features of
DSM-IV subtypes of attention-deficit/hyperactivity disorder:
Results from a clinically referred sample.
Journal of the American Academy of Child and Adolescent
Psychiatry
37,
185–193.Google Scholar
Filipek, P. A.,
Semrud–Clikeman, M.,
Steingard, R. J.,
Renshaw, P. F.,
Kennedy, D. N., &
Biederman, J.
(1997).
Volumetric MRI analysis comparing subjects having attention-deficit
hyperactivity disorder with normal controls.
Neurology
48,
589–601.Google Scholar
Frick, P. J.,
Lahey, B. B.,
Applegate, B.,
Kerdyck, L.,
Ollendick, T.,
Hynd, G. W.,
Garfinkel, B.,
Greenhill, L.,
Biederman, J.,
Barkley, R. A.,
McBurnett, K.,
Newcorn, J., &
Waldman, I.
(1994).
DSM-IV field trials for the disruptive behaviour disorders:
Symptom utility estimates.
Journal of the American Academy of Child & Adolescent
Psychiatry
33,
529–539.Google Scholar
Fry, A. F., &
Hale, S.
(1996).
Processing speed, working memory, and fluid intelligence: Evidence
for a developmental cascade.
Psychological Science
7,
237–241.Google Scholar
Garris, P. A., &
Wightman, R. M.
(1994).
Different kinetics govern dopaminergic transmission in the amygdala,
prefrontal cortex, and striatum: An in vivo voltametric
study.
Journal of Neuroscience
14,
442–450.Google Scholar
Gascon, G.,
Johnson, R., &
Burd, L.
(1986).
Central auditory processing and attention deficit disorders.
Journal of Child Neurology
1,
27–33.Google Scholar
Ghelani, K.,
Sidhu, R.,
Jain, U., &
Tannock, R.
(2004).
Reading comprehension and reading related abilities in adolescents
with reading disabilities and attention-deficit/hyperactivity
disorder.
Dyslexia
10,
364–384.Google Scholar
Gill, M.,
Daly, G.,
Heron, S.,
Hawl, Z., &
Fitzgerald, M.
(1997).
Confirmation of association between attention deficit hyperactivity
disorder and a dopamine transporter polymorphism.
Molecular Psychiatry
2,
311–313.Google Scholar
Goldman–Rakic, P. S.
(1987).
Development of cortical circuitry and cognitive function.
Child Development
58,
601–622.Google Scholar
Goodyear, P., &
Hynd, G.
(1992).
Attention-deficit disorder with and without hyperactivity:
Behavioral and neuropsychological differentiation.
Journal of Clinical Child Psychology
21,
273–305.Google Scholar
Hale, T. S.,
Hariri, A. R., &
McCracken, J. T.
(2000).
Attention deficit/hyperactivity disorder: Perspectives from
neuroimaging.
Mental Retardation and Developmental Disabilities
6,
214–219.Google Scholar
Hamarman, S.,
Fossella, J.,
Ulger, C.,
Brimacombe, M., &
Dermody, J.
(2004).
Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate
dose response in children with attention deficit hyperactivity disorder: A
pharmacogenetic study.
Journal of Child and Adolescent Psychopharmacology
14,
564–574.Google Scholar
Hartman, C. A.,
Willcutt, E. G.,
Rhee, S. H., &
Pennington, B. F.
(2004).
The relation between sluggish cognitive tempo and DSM-IV
ADHD.
Journal of Abnormal Child Psychology
32(5),
491–503.Google Scholar
Hasher, L., &
Zacks, R. T.
(1988).
Working memory, comprehension, and aging: A review and a new
view. In
G. H. Bower (Ed.),
The psychology of learning and motivation: Advances in research and
theory
(Vol. 22, pp.
193–225).
San Diego, CA:
Academic Press.
Heilman, K. M.,
Voeller, K. S., &
Nadeau, S. E.
(1991).
A possible pathophysiologic substrate of attention deficit
hyperactivity disorder.
Journal of Child Neurology
6,
76–81.Google Scholar
Herrigel, E., &
Suzuki, D. T.
(1953).
Zen in the art of archery.
New York:
Pantheon Books.
Hinshaw, S. P.
(2002).
Preadolescent girls with attention-deficit/hyperactivity
disorder: I. Background characteristics, comorbidity, cognitive and social
functioning, and parenting practices.
Journal of Consulting and Clinical Psychology
70,
1086–1098.Google Scholar
Hitch, G. J.,
Towse, J. N., &
Hutton, U.
(2001).
What limits children's working memory span? Theoretical
accounts and applications for scholastic development.
Journal of Experimental Psychology: General
130,
184–198.Google Scholar
Holdnack, J. A.,
Moberg, P. J.,
Arnold, S. E., &
Gur, R. C.
(1995).
Speed of processing and verbal learning deficits in adults diagnosed
with attention deficit disorder.
Neuropsychiatry, Neuropsychology, and Behavioral Neurology
8,
282–292.Google Scholar
Hynd, G.,
Nieves, N.,
Connor, R.,
Stone, P.,
Town, P., &
Becker, M.
(1989).
Attention deficit disorder with and without hyperactivity: Reaction
time and speed of cognitive processing.
Journal of Learning Disabilities
22,
573–580.Google Scholar
Hynd, G. W.,
Hern, K. L.,
Novey, E. S.,
Eliopulos, D.,
Marshall, R.,
Gonzalez, J. J., &
Voeller, K. K.
(1993).
Attention deficit-hyperacitivity disorder and asymmetry of the
caudate nucleus.
Journal of Child Neurology
8,
339–347.Google Scholar
Hynd, G. W.,
Lorys, A. R.,
Semrud–Clikeman, M.,
Nieves, N.,
Huettner, M. I., &
Lahey, B. B.
(1991).
Attention deficit disorder without hyperactivity: A distinct
behavioral and neurocognitive syndrome.
Journal of Child Neurology
6,
37–43.Google Scholar
Ishimatsu, M.,
Kidani, Y.,
Tsuda, A., &
Akasu, T.
(2002).
Effects of methylphenidate on the membrane potential and current in
neurons of the rat locus coeruleus.
Journal of Neurophysiology
87,
1206–1212.Google Scholar
Jucaite, A.,
Fernell, E.,
Halldin, C.,
Forssberg, H., &
Farde, L.
(2005).
Reduced midbrain dopamine transporter binding in male adolescents
with attention-deficit/hyperactivity disorder: Association between
striatal dopamine markers and motor hyperactivity.
Biological Psychiatry
57,
229–238.Google Scholar
Just, M. A., &
Carpenter, P. A.
(1992).
A capacity theory of comprehension: Individual differences in
working memory.
Psychological Review
99,
122–149.Google Scholar
Kail, R.
(1992).
Processing, speed, speech rate, and memory.
Developmental Psychology
28,
899–904.Google Scholar
Kail, R., &
Salthouse, T. A.
(1994).
Processing speed as a mental capacity.
Acta Psychologica
86,
199–225.Google Scholar
Kane, M. J.,
Bleckley, M.,
Conway, A. R., &
Engle, R. W.
(2001).
A controlled-attention view of working-memory capacity.
Journal of Experimental Psychology: General
130,
169–183.Google Scholar
Kane, M. J., &
Engle, R. W.
(2000).
Working-memory capacity, proactive interference, and divided
attention: Limits on long-term memory retrieval.
Journal of Experimental Psychology
26,
336–358.Google Scholar
Kane, M. J., &
Engle, R. W.
(2002).
The role of prefrontal cortex in working-memory capacity, executive
attention, and general fluid intelligence: An individual-differences
perspective.
Psychonomic Bulletin & Review
9,
637–671.Google Scholar
Krause, K. H.,
Dresel, S. H.,
Krause, J.,
Kung, H. F., &
Tatsch, K.
(2000).
Increased striatal dopamine transporter in adult patients with
attention deficit hyperactivity disorder: Effects of methylphenidate as
measured by single photon emission computed tomography.
Neuroscience Letters
285,
107–110.Google Scholar
Krause, K. H.,
Dresel, S. H.,
Krause, J.,
Kung, H. F.,
Tatsch, K., &
Ackenheil, M.
(2002).
Stimulant-like action of nicotine on striatal dopamine transporter
in the brain of adults with attention deficit hyperactivity
disorder.
International Journal of Neuropsychopharmacology
5,
111–113.Google Scholar
Krause, K.-H.,
Dresel, S. H.,
Krause, J.,
la Fougere, C., &
Ackenheil, M.
(2003).
The dopamine transporter and neuroimaging in attention deficit
hyperactivity disorder.
Neuroscience & Biobehavioral Reviews
27,
605–613.Google Scholar
LaBar, K. S.,
Gitelman, D. R.,
Parrish, T. B., &
Mesulam, M.
(1999).
Neuroanatomic overlap of working memory and spatial attention
networks: A functional MRI comparison within subjects.
NeuroImage
10,
695–704.Google Scholar
Lahey, B. B., &
Carlson, C.
(1991).
Validity of the diagnostic category of attention deficit disorder
without hyperactivity: A review of the literature.
Journal of Learning Disabilities
24,
110–120.Google Scholar
Lahey, B. B.,
Schaughency, E.,
Hynd, G.,
Carlson, C., &
Niever, C.
(1987).
Attention deficit disorder with and without hyperactivity:
Comparison of behavioral characteristics of clinic referred
children.
Journal of the American Academy of Child and Adolescent
Psychiatry
26,
718–723.Google Scholar
Lang, A. E., &
Johnson, K.
(1987).
Akathisia in idiopathic Parkinson's disease.
Neurology
37,
477–480.Google Scholar
Lipschutz, B.,
Kolinsky, R.,
Damhaut, P.,
Wikler, D., &
Goldman, S.
(2001).
Attention-dependent changes of activation and connectivity in
dichotic listening: Evidence from two studies.
NeuroImage,
13,
S327.Google Scholar
Lorch, E. P.,
Milich, R.,
Sanchez, R. P.,
van den Broek, P.,
Baer, S.,
Hooks, K.,
Hartung, C., &
Welsh, R.
(2000).
Comprehension of televised stories in boys with attention
deficit/hyperactivity disorder and nonreferred boys.
Journal of Abnormal Psychology
109,
321–330.Google Scholar
Lou, H. C.,
Hendriksen, L., &
Bruhn, P.
(1984).
Focal cerebral hypoperfusion in children with dysphasia and/or
attention deficit disorder.
Archives of Neurology
41,
825–829.Google Scholar
Lou, H. C.,
Hendriksen, L.,
Bruhn, P.,
Borner, H., &
Nielsen, J. B.
(1989).
Striatal dysfunction in attention deficit and hyperkinetic
disorder.
Archives of Neurology
46,
48–52.Google Scholar
Luman, M.,
Oosterlaan, J. A., &
Sergeant, J.
(2005).
The impact of reinforcement contingencies on AD/HD: A review and
theoretical appraisal.
Clinical Psychology Review
25,
183–213.Google Scholar
Luria, A. R.
(1973).
The working brain: An introduction to neuropsychology.
New York:
Basic Books.
Maedgen, J. W., &
Carlson, C. L.
(2000).
Social functioning and emotional regulation in the attention deficit
hyperactivity disorder subtypes.
Journal of Clinical Child Psychology
29,
30–42.Google Scholar
Marshall, R. M.,
Hynd, G. W.,
Handwerk, M. J., &
Hall, J.
(1997).
Academic underachievement in ADHD subtypes.
Journal of Learning Disabilities
30,
635–642.Google Scholar
Mariani, M., &
Barkley, R. A.
(1997).
Neuropsychological and academic functioning in preschool boys with
attention deficit hyperactivity disorder.
Developmental Neuropsychology
13,
111–129.Google Scholar
Mataro, M.,
Garcia–Sanchez, C.,
Junque, C.,
Estevez–Gonzalez, A., &
Pujol, J.
(1997).
Magnetic resonance imaging measurement of the caudate nucleus in
adolescents with attention-deficit hyperactivity disorder and its
relationship with neuropsychological and behavioural measures.
Archives of Neurology
54,
963–968.Google Scholar
McInnes, A.,
Humphries, T.,
Hogg–Johnson, S., &
Tannock, R.
(2003).
Listening comprehension and working memory are impaired in
attention-deficit hyperactivity disorder irrespective of language
impairment.
Journal of Abnormal Child Psychology
31,
427–443.Google Scholar
Meador–Woodruff, J. H.,
Damask, S. P.,
Wang, J.,
Haroutunian, V.,
Davis, K. L., &
Watson, S. J.
(1996).
Dopamine receptor mRNA expression in human striatum and
neocortex.
Neuropsychopharmacology
15,
17–29.Google Scholar
Menna, R.
(1989).
Working memory and development: An EEG Investigation.
Unpublished manuscript,
University of Toronto.
Miles, C.,
Morgan, M. J.,
Milne, A. B., &
Morris, E. D. M.
(1996).
Developmental and individual differences in visual memory
span.
Current Psychology
15,
53–67.Google Scholar
Milich, R.,
Balentine, A. C., &
Lynam, D. R.
(2001).
ADHD combined type and ADHD predominantly inattentive type are
distinct and unrelated disorders.
Clinical Psychology: Science and Practice
8,
463–488.Google Scholar
Milich, R. S., &
Loney, J.
(1979).
The factor composition of the WISC for hyperkinetic/MBD
males.
Journal of Learning Disabilities
12,
491–495.Google Scholar
Miller, B. T.,
Verstynen, T.,
Raye, C. L.,
Mitchell, K. J.,
Johnson, M. K., &
D'Esposito, M.
(2003).
The role of dorsolateral PFC in refreshing just-activated
information: A TMS study.
Society of Neuroscience,
287,
211.Google Scholar
Miyake, A., &
Shah, P.
(1999).
Models of working memory: Mechanisms of active maintenance and
executive control.
New York:
Cambridge University Press.
Morgan, S. T.,
Hansen, J. C., &
Hillyard, S. A.
(1996).
Selective attention to stimulus location modulates the steady-state
visual evoked potential.
Proceedings of the National Academy of Sciences
93,
4770–4774.Google Scholar
Nigg, J. T.
(2000).
On inhibition/disinhibition in developmental psychopathology:
Views from cognitive and personality psychology and a working inhibition
taxonomy.
Psychological Bulletin
126,
220–246.Google Scholar
Nigg, J. T.
(2001).
Is ADHD an inhibitory disorder?
Psychological Bulletin
127,
571–598.Google Scholar
Nigg, J. T.,
Blaskey, L. G.,
Huang–Pollock, C. L., &
Rappley, M. D.
(2002).
Neuropsychological executive functions and DSM-IV ADHD
subtypes.
Journal of the American Academy of Child and Adolescent
Psychiatry
41,
59–66.Google Scholar
Owen, A. M.
(1997).
The functional organization of working memory processes within human
lateral frontal cortex: The contribution of functional
neuroimaging.
European Journal of Neuroscience
9,
1329–1339.Google Scholar
Park, D. C., &
Payer, D.
(2005).
Working memory across the adult life span. In
E. Bialystok &
F. Craik (Eds.),
Lifespan cognition: Mechanisms of change.
Oxford:
Oxford University Press.
Pascual–Leone, J. A.
(1970).
A mathematical model for transition in Piaget's developmental
stages.
Acta Psychologia
32,
301–345.Google Scholar
Peers, P. V.,
Ludwig, C. J. H.,
Rorden, C.,
Cusack, R.,
Bonfiglioli, C.,
Bundesen, C.,
Driver, J.,
Antoun, N., &
Duncan, J.
(2005).
Attentional functions of parietal and frontal cortex.
Cerebral Cortex.Google Scholar
Pennington, B. F., &
Ozonoff, S.
(1996).
Executive functions and developmental psychopathology.
Journal of Child Psychology and Psychiatry
37,
51–87.Google Scholar
Petrides, M.
(1995).
Functional organization of the human frontal cortex for mnemonic
processing: Evidence from neuroimaging studies.
Annals of the New York Academy of Sciences
769,
85–96.Google Scholar
Petrides, M.
(1996).
Specialized systems for the processing of mnemonic information
within the primate frontal cortex.
Philosophical Transactions of the Royal Society of London
351,
1455–1462.Google Scholar
Pomerleau, C. S.
(1997).
Co-factors for smoking and evolutionary psychobiology.
Addiction
92,
397–408.Google Scholar
Powell, K. B., &
Voeller, K. K.
(2004).
Prefrontal executive function syndromes in children.
Journal of Child Neurology
19,
785–797.Google Scholar
Pugzles Lorch, E.,
Milich, R., &
Sanchez, R. P.
(1998).
Story comprehension in children with ADHD.
Clinical Child and Family Psychology Review
1,
163–178.Google Scholar
Ravizza, S. M.,
Delgado, M. R.,
Chein, J. M.,
Becker, J. T., &
Fiez, J. A.
(2004).
Functional dissociations within the inferior parietal cortex in
verbal working memory.
NeuroImage
22,
562–573.Google Scholar
Riccio, C. A.,
Hynd, G. W.,
Cohen, M. J.,
Hall, J.
(1994).
Comorbidity of central auditory processing disorder and
attention-deficit hyperactivity disorder.
Journal of the American Academy of Child and Adolescent
Psychiatry
33,
849–857.Google Scholar
Rivera, S. M.,
Reiss, A. L.,
Eckert, M. A., &
Menon, V.
(2005).
Developmental changes in mental arithmetic: Evidence for increased
functional specialization in the left inferior parietal cortex.
Cerebral Cortex.Google Scholar
Rowe, D. C.,
Stever, C.,
Giedinghagen, L. N.,
Gard, J. M.,
Cleveland, H. H.,
Terris, S. T.,
Mohr, J. H.,
Sherman, S.,
Abramowitz, A., &
Waldman, I. D.
(1998).
Dopamine DRD4 receptor polymorphism and attention deficit
hyperactivity disorder.
Molecular Psychiatry
3,
419–426.Google Scholar
Rueckert, L., &
Grafman, J.
(1998).
Sustained attention deficits in patients with lesions of posterior
cortex.
Neuropsychologia
36,
653–660.Google Scholar
Salthouse, T. A.
(1992).
Influence of processing speed on adult age differences in working
memory.
Acta Psychologica
79,
155–170.Google Scholar
Salthouse, T. A.
(1993).
Speed mediation of adult age differences in cognition.
Developmental Psychology
29,
722–738.Google Scholar
Salthouse, T. A., &
Meinz, E. J.
(1995).
Aging, inhibition, working memory, and speed.
Journal of Gerontology Series B, Psychological Sciences and Social
Sciences
50,
297–306.Google Scholar
Sanchez, R. P.,
Lorch, E. P.,
Milich, R., &
Welsh, R.
(1999).
Comprehension of televised stories by preschool children with
ADHD.
Journal of Clinical Child Psychology
28,
376–385.Google Scholar
Sanchez–Gonzalez, M. A., &
Cavada, C.
(2003).
Dopamine transporter expression in the primate brain.
Paper presented at the Society for Neuroscience, 33rd Annual
Meeting [2003 Abstract Viewer/Itinerary Planner].
Schrimsher, G. W.,
Billingsley, R. L.,
Jackson, E. F., &
Moore, B. D.
(2002).
Caudate nucleus volume asymmetry predicts attention-deficit
hyperactivity disorder (ADHD) symptomatology in children.
Journal of Child Neurology
17,
877–884.Google Scholar
Seeman, P., &
Madras, B. K.
(1998).
Anti-hyperactivity medication: Methylphenidate and
amphetamine.
Molecular Psychiatry
3,
386–396.Google Scholar
Sergeant, J. A.,
Geurts, H.,
Huijbregts, S.,
Scheres, A., &
Oosterlaan, J.
(2003).
The top and the bottom of ADHD: A neuropsychological
perspective.
Neuroscience & Biobehavioral Reviews
27,
583–592.Google Scholar
Sesack, S. R.,
Hawrylak, V. A.,
Matus, C.,
Guido, M. A., &
Levey, A. I.
(1998).
Dopamine axon varicosities in the prelimbic division of the rat
prefrontal cortex exhibit sparse immunoreactivity for the dopamine
transporter.
Journal of Neuroscience
18,
2697–2708.Google Scholar
Shenker, A.
(1992).
The mechanism of action of drugs used to treat attention-deficit
hyperactivity disorder: Focus on catecholoamine receptor
pharmacology.
Advanced Pediatrics
39,
337–382.Google Scholar
Shue, K. L., &
Douglas, V. I.
(1992).
Attention deficit hyperactivity disorder and the frontal lobe
syndrome.
Brain and Cognition
20,
104–124.Google Scholar
Siegel, L.
(1994).
Working memory and reading: A lifespan perspective.
International Journal of Behavioural Development
17,
109–124.Google Scholar
Simon, O.,
Mangin, J.-F.,
Cohen, L.,
Le Bihan, D., &
Dehaene, S.
(2002).
Topographical layout of hand, eye, calculation, and language-related
areas in the human parietal lobe.
Neuron
33,
475–487.Google Scholar
Smith, E. E., &
Jonides, J.
(1999).
Storage and executive processes in the frontal lobes.
Science
283,
1657–1661.Google Scholar
Smith, E. E.,
Jonides, J.,
Marshuetz, C., &
Koeppe, R. A.
(1998).
Components of verbal working memory: Evidence from
neuroimaging.
Proceedings of the National Academy of Sciences
95,
876–882.Google Scholar
Stanford, L. D., &
Hynd, G. W.
(1994).
Congruence of behavioral symptomatology in children with ADD/H,
ADD/WO, and learning disabilities.
Journal of Learning Disabilities
27,
243–253.Google Scholar
Stuss, D. T., &
Benson, D. F.
(1986).
The frontal lobes.
New York:
Raven Press.
Swanson, J. M.,
Flodman, P.,
Kennedy, J.,
Spence, M. A.,
Moyzis, R.,
Schuck, S.,
Murias, M.,
Moriarty, J.,
Barr, C.,
Smith, M., &
Posner, M.
(2000).
Dopamine genes and ADHD.
Neuroscience and Biobehavioral Reviews
24.Google Scholar
Sykes, D. H.,
Douglas, V. I.,
Weiss, G., &
Minde, K.
(1971).
Attention in hyperactive children and the effect of methylphenidate
(Ritalin).
Journal of Child Psychology and Psychiatry
12,
129–139.Google Scholar
Szatmari, P.
(1992).
The epidemiology of attention-deficit hyperactivity
disorders. In
G. Weiss (Ed.),
Child and adolescent psychiatry clinics of North America: Attention
deficit disorder (pp.
361–372).
Philadelphia, PA:
Saunders.
Teicher, M. H.,
Ito, Y.,
Glod, C. A., &
Barber, N. I.
(1996).
Objective measurement of hyperactivity and attentional problems in
ADHD.
Journal of the American Academy of Child and Adolescent
Psychiatry
35,
334–342.Google Scholar
Tercyak, K. P.,
Lerman, C., &
Audrain, J.
(2002).
Association of attention-deficit hyperactivity disorder symptoms
with levels of cigarette smoking in a community sample of
adolescents.
Journal of the American Academy of Child and Adolescent
Psychiatry
41,
799–805.Google Scholar
Vaidya, C. J.,
Austin, G.,
Kirkorian, G.,
Ridlehuber, H. W.,
Desmond, J. E.,
Glover, G. H., &
Gabrieli, J. D.
(1998).
Selective effects of methylphenidate in attention deficit
hyperactivity disorder: A functional magnetic resonance study.
Proceedings of the National Academy of Sciences of the United States
of America
95,
14494–14499.Google Scholar
van der Meere, J., &
Sergeant, J.
(1988).
Acquisition of attentional skill in pervasively hyperactive
children.
Journal of Child Psychology and Psychiatry
29,
301–310.Google Scholar
van der Meere, J.,
Wekking, E. E.,
Sergeant, J.
(1991).
Sustained attention and pervasive hyperactivity.
Journal of Child Psychology and Psychiatry, and Allied
Disciplines
2,
275–284.Google Scholar
van Honk, J.,
Schutter, D. J.,
Putman, P.,
de Haan, E. H., &
d'Alfonso, A. A.
(2003).
Reductions in phenomenological, physiological and attentional
indices of depressive mood after 2 Hz rTMS over the right parietal cortex
in healthy human subjects.
Psychiatry Research
120,
95–101.Google Scholar
Volkow, N. D.,
Gur, R. C.,
Wang, G.-J.,
Fowler, J. S.,
Moberg, P. J.,
Ding, Y.-S.,
Hitzemann, R.,
Smith, G., &
Logan, J.
(1998).
Association between decline in brain dopamine activity with age and
cognitive and motor impairment in healthy individuals.
American Journal of Psychiatry
155,
344–349.Google Scholar
Waldman, I. D.,
Rowe, D. C.,
Abramowitz, A.,
Kozel, S. T.,
Mohr, J. H.,
Sherman, S. L.,
Cleveland, H. H.,
Sanders, M. L.,
Gard, J. M., &
Stever, C.
(1998).
Association and linkage of the dopamine transporter gene and
attention deficit hyperactivity disorder in children: Owing to diagnostic
subtype and severity.
American Journal of Human Genetics
63,
1767–1776.Google Scholar
Warner–Rogers, J.,
Taylor, A.,
Taylor, E., &
Sandberg, S.
(2000).
Inattentive behaviour in childhood: Epidemiology and implications
for development.
Journal of Learning Disabilities
33,
520–536.Google Scholar
Weiler, M. D.,
Holmes–Bernstein, J.,
Bellinger, D. C., &
Waber, D. P.
(2000).
Processing speed in children with attention
deficit/hyperactivity disorder, inattentive type.
Child Neuropsychology
6,
218–234.Google Scholar
Weiss, G., &
Hechtman, L.
(1979).
The hyperactive child syndrome.
Science
205,
1348–1354.Google Scholar
Weiss, M.,
Worling, D., &
Wasdell, M.
(2003).
A chart review study of the inattentive and combined types of
ADHD.
Journal of Attention Disorders
7,
1–9.Google Scholar
Welsh, M. C., &
Pennington, B. F.
(1988).
Assessing frontal lobe functioning in children: Views from
developmental psychology.
Developmental Neuropsychology
4,
199–230.Google Scholar
Westerberg, H.,
Hirvikoski, T.,
Forssberg, H., &
Klingberg, T.
(2004).
Brief report-visuo-spatial working memory span: A sensitive measure
of cognitive deficits in children with ADHD.
Child Neuropsychology
10,
155–161.Google Scholar
Whalen, C.,
Jamner, L. D.,
Henker, B.,
Gehricke, J. G., &
King, P. S.
(2003).
Is there a link between adolescent cigarette smoking and
pharmacotherapy for ADHD?
Psychology of Addictive Behaviors
17,
332–335.Google Scholar
Willcutt, E. G., &
Pennington, B. F.
(2000).
Comorbidity of reading disability and
attention-deficit/hyperactivity disorder: Differences by gender and
subtype.
Journal of Learning Disabilities
33,
179–191.Google Scholar
Wilson, B. A.,
Evans, J. J.,
Emslie, H.,
Alderman, N., &
Burgess, P.
(1998).
The development of an ecologically valid test for assessing patients
with a dysexecutive syndrome.
Neuropsychological Rehabilitation
8,
213–228.Google Scholar
Wilson, J. T. L.,
Scott, J. H., &
Power, K. G.
(1987).
Developmental differences in the span of visual memory for
pattern.
British Journal of Developmental Psychology
5,
249–255.Google Scholar
Zametkin, A.,
Liebenauer, L. L.,
Fitzgerald, G. A.,
King, A.,
Minkunas, D.,
Herscovitch, P.,
Yamada, E., &
Cohen, R.
(1993).
Brain metabolism in teenagers with attention deficit hyperactivity
disorder.
Archives of General Psychiatry
50,
333–340.Google Scholar
Zentall, S. S., &
Smith, Y. S.
(1993).
Mathematical performance and behavior of children with hyperactivity
with and without coexisting aggression.
Behavior Research and Therapy.Google Scholar
- 310
- Cited by